1,4 oxazines as bace1 and/or bace2 inhibitors

1,4-oxazines en tant qu'inhibiteurs de bace1 et/ou bace2

Abstract

La présente invention concerne des 1,4-oxazines de formule (I) ayant une activité inhibitrice de BACE1 et/ou BACE2, leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation en tant que substances thérapeutiquement actives. Les composés de la présente invention sont utiles dans le traitement thérapeutique et/ou prophylactique, par exemple, de la maladie d'Alzheimer et du diabète de type 2.
The present invention relates to 1,4 Oxazines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

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Cited By (5)

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    US-8883779-B2November 11, 2014Shinogi & Co., Ltd.Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
    US-8895548-B2November 25, 2014Shionogi & Co., Ltd.Pharmaceutical composition for treating alzheimer's disease
    US-8927721-B2January 06, 2015Shionogi & Co., Ltd.Naphthyridine derivative
    US-8999980-B2April 07, 2015Shionogi & Co., Ltd.Oxazine derivatives
    US-9273053-B2March 01, 2016Shionogi & Co., Ltd.Sulfur-containing heterocyclic derivative having Beta secretase inhibitory activity